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Progynova (estradiol valerate) 1 mg oral tablets in the Chinese mainland. Side effects of estradiol valerate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [15] [13] [14] Estradiol valerate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol.
Average number of moderate-to-severe hot flashes per week with placebo and different doses of oral estradiol in menopausal women [40] [41]. Estradiol is used in menopausal hormone therapy to prevent and treat moderate to severe menopausal symptoms such as hot flashes, vaginal dryness and atrophy, and osteoporosis (bone loss). [11]
Estradiol cypionate (Depo-Estradiol, Estradiol Cypionate) – 5 mg/mL (1 mg/mL and 3 mg/mL discontinued) Estradiol valerate (Delestrogen, Estradiol Valerate) – 10 mg/mL, 20 mg/mL, 40 mg/mL; Polyestradiol phosphate (Estradurin) was previously available in the U.S. but was discontinued.
Estradiol is not produced in the gonads only; in particular, fat cells produce active precursors to estradiol, and will continue to do so even after menopause. [51] Estradiol is also produced in the brain and in arterial walls. In men, approximately 15 to 25% of circulating estradiol is produced in the testicles.
1.38 (1.23–1.56)* 1.84 (1.69–2.00)* Estradiol/norgestrel or estradiol/drospirenone: 1.42 (1.00–2.03) Conjugated estrogens/medroxyprogesterone acetate: 2.10 (1.92–2.31)* Conjugated estrogens/norgestrel ≤0.625 mg/day CEEs >0.625 mg/day CEEs: 1.73 (1.57–1.91)* 1.53 (1.36–1.72)* 2.38 (1.99–2.85)* Tibolone alone: 1.02 (0.90–1.15 ...
Estradiol/norgestrel or estradiol/drospirenone: 1.42 (1.00–2.03) ... weight gain while others report weight loss. Several mechanisms for weight gain have been ...