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MDCalc is a free online medical reference for healthcare professionals that provides point-of-care clinical decision-support tools, including medical calculators, scoring systems, and algorithms. [1] MDCalc is also a mobile and web app. [ 2 ] The decision-support tools are based on published clinical research, [ 3 ] and MDCalc’s content is ...
Linezolid is a member of the oxazolidinone class of medications. [10] Linezolid was discovered in the mid-1990s, and was approved for commercial use in 2000. [16] [17] It is on the World Health Organization's List of Essential Medicines. [18] The World Health Organization classifies linezolid as critically important for human medicine. [19]
Linezolid (Zyvox), which is available for intravenous administration and also has the advantage of having excellent oral bioavailability. Posizolid , which appears to have excellent, targeted bactericidal activity against all common gram-positive bacteria, regardless of resistance to other classes of antibiotics.
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A case report describing symptomatic hypoglycemia in a linezolid recipient prompted a review of the US Food and Drug Administration Adverse Event Reporting System, which demonstrated a relationship between linezolid and hypoglycemia. A warning with this information was added to the linezolid package insert.
Skeletal formulae of the antibiotic linezolid (top) and the anticoagulant rivaroxaban (bottom), highlighting their similar oxazolidinone core (in blue). Created using ACD/ChemSketch 10.0 and Inkscape. Date: 11 June 2009: Source: Own work. The structural similarity between the drugs is discussed in European Medicines Agency (2008).
It differs from linezolid by replacement of the morpholine oxygen with a sulfur atom. Like linezolid, sutezolid is a bacterial protein synthesis inhibitor . In preclinical studies, sutezolid demonstrated superior antituberculosis activity compared to linezolid.
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