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[3] [2] [4] The modafinil analogues are of interest in the potential treatment of a condition involving the misuse of stimulant drugs (psychostimulant use disorder or PSUD), as drugs that help increase motivation (pro-motivational agents) to treat motivational disorders, [4] [5] [6] and for treatment of neurodegenerative diseases such as ...
Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant and eugeroic (wakefulness promoter) medication used primarily to treat narcolepsy, [3] [8] [15] a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks. [16]
A Cephalon-founded study in which patients were administered modafinil, methylphenidate, and a placebo found that modafinil produces "psychoactive and euphoric effects and feelings consistent with [methylphenidate]." [12] Like modafinil, armodafinil is an inhibitor and/or inducer of certain cytochrome P450 enzymes.
Esmodafinil has been researched for the treatment of cocaine addiction. [ 5 ] [ 6 ] Like armodafinil, esmodafinil attenuates the effects of cocaine by occupying the dopamine transporter. [ 6 ] While doing so, esmodafinil increases dopamine levels in the nucleus accumbens to a lesser extent than cocaine . [ 5 ]
Eugeroics, in the sense of modafinil-type wakefulness promoting agents, include modafinil itself, armodafinil, and adrafinil, among others. [9] They are medically indicated for the treatment of certain sleep disorders, including excessive daytime sleepiness (EDS) in narcolepsy or obstructive sleep apnea (OSA).
As with so many other public health policies—many of which were on obvious display during the COVID-19 pandemic—alcohol guidelines focused exclusively on physical well-being at the expense of ...
Flmodafinil (developmental code names CRL-40,940, NLS-4, JBG01-41), also known as bisfluoromodafinil and lauflumide, is a wakefulness-promoting agent related to modafinil which has been developed for treatment of a variety of different medical conditions.
They majored in drug dealing. Six Rutgers University students and one alum were charged this week with running a sophisticated drug ring — and allegedly used a “private social media network ...
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