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Atypical hyperplasia is a high-risk premalignant lesion of the breast. It is believed that atypical ductal hyperplasia (ADH) is a direct precursor for low-grade mammary ductal carcinoma , whereas atypical lobular hyperplasia (ALH) serves as a risk indicator.
The lobules and acini of the terminal duct-lobular unit (TDLU), the basic functional unit of the breast, may become distorted and undergo expansion due to the abnormal proliferation of cells comprising the structure. [2] These changes represent a spectrum of atypical epithelial lesions that are broadly referred to as lobular neoplasia (LN).
Presence of high-risk breast lesions like lobular carcinoma in situ (LCIS), atypical ductal hyperplasia (ADH) and atypical lobular hyperplasia (ALH). [7] Having dense breasts or breasts with diffuse microcalcification, as the screening for breast cancer is made difficult.
There are two types of atypical hyperplasia: lobular and ductal; the lobular type is associated a greater cancer risk of approximately five-fold and especially high relative risk in premenopausal women. Atypical ductal hyperplasia is associated with a 2.4-fold risk. [20]
2 External links. Toggle the table of contents. ... Examples include atypical ductal hyperplasia, atypical lobular hyperplasia, and intraductal papillomas. References
WASHINGTON (Reuters) - -Alcoholic drinks should carry a label warning consumers about their cancer risks, the U.S. Surgeon General said in an advisory on Friday, noting that their consumption ...
Atypical ductal hyperplasia (ADH) is the term used for a benign lesion of the breast that indicates an increased risk of breast cancer. [1]The name of the entity is descriptive of the lesion; ADH is characterized by cellular proliferation (hyperplasia) within one or two breast ducts and (histomorphologic) architectural abnormalities, i.e. the cells are arranged in an abnormal or atypical way ...
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