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The carbylamine reaction (also known as the Hoffmann isocyanide synthesis) is the synthesis of an isocyanide by the reaction of a primary amine, chloroform, and base. The conversion involves the intermediacy of dichlorocarbene .
An isocyanide (also called isonitrile or carbylamine) is an organic compound with the functional group – N + ≡C −. It is the isomer of the related nitrile (–C≡N), hence the prefix is isocyano. [1] The organic fragment is connected to the isocyanide group through the nitrogen atom, not via the carbon. They are used as building blocks ...
Methyl isocyanate (MIC) is an organic compound with the molecular formula CH 3 NCO. Synonyms are isocyanatomethane and methyl carbylamine.Methyl isocyanate is an intermediate chemical in the production of carbamate pesticides and Haffmann Bromamide Degradation (such as carbaryl, carbofuran, methomyl, and aldicarb).
Dichlorocarbene is an intermediate in the carbylamine reaction. In this conversion, a dichloromethane solution of a primary amine is treated with chloroform and aqueous sodium hydroxide in the presence of catalytic amount of the phase-transfer catalyst. Illustrative is the synthesis of tert-butyl isocyanide: [7]
tert-Butyl isocyanide is an organic compound with the formula Me 3 CNC (Me = methyl, CH 3).It is an isocyanide, commonly called isonitrile or carbylamine, as defined by the functional group C≡N-R. tert-Butyl isocyanide, like most alkyl isocyanides, is a reactive colorless liquid with an extremely unpleasant odor.
Blum–Ittah aziridine synthesis; Bodroux reaction; Bodroux–Chichibabin aldehyde synthesis; Bogert–Cook synthesis; Bohlmann-Rahtz pyridine synthesis; Bohn–Schmidt reaction; Boord olefin synthesis; Borodin reaction; Borsche–Drechsel cyclization; Bosch–Meiser urea process; Bosch reaction; Bouveault aldehyde synthesis; Bouveault–Blanc ...
The Hofmann rearrangement (Hofmann degradation) is the organic reaction of a primary amide to a primary amine with one less carbon atom. [1] [2] [3] The reaction involves oxidation of the nitrogen followed by rearrangement of the carbonyl and nitrogen to give an isocyanate intermediate.
Fatty acid synthesis proceeds via ketones. Acetoacetate is an intermediate in the Krebs cycle which releases energy from sugars and carbohydrates. [22] In medicine, acetone, acetoacetate, and beta-hydroxybutyrate are collectively called ketone bodies, generated from carbohydrates, fatty acids, and amino acids in most vertebrates, including humans.