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Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene. [5] [6] Interactions. SUPT5H has been shown to interact with:
Factors of the Spt4/Spt5 family (bacterial homolog of Spt5 is called NusG) stimulate transcription by binding to the RNAP clamp on one side of the DNA channel and to the gate loop on the other. The resultant DSIF locks the clamp into a closed state to prevent the elongation complex (EC) from dissociating.
This stalling is relieved by positive transcription elongation factor b (P-TEFb) and Pol II enters productive elongation to resume synthesis till finish. [1] In humans, DSIF is composed of hSPT4 and hSPT5. [2] hSPT5 has a direct role in mRNA capping which occurs while the elongation is paused. [4] SPT5 is preserved in humans to bacteria. [5]
The positive transcription elongation factor, P-TEFb, is a multiprotein complex that plays an essential role in the regulation of transcription by RNA polymerase II (Pol II) in eukaryotes. [1] Immediately following initiation Pol II becomes trapped in promoter proximal paused positions on the majority of human genes (Figure 1).
One of the elongation factors, P-TEFb, is particularly important. [25] P-TEFb phosphorylates the second residue (Ser-2) of the CTD repeats (YSPTSPS) of the bound Pol II. P-TEFb also phosphorylates and activates SPT5 and TAT-SF1. SPT5 is a universal transcription factor that helps recruit 5'-capping enzyme to Pol II with a CTD phosphorylated at ...
58202 Ensembl ENSG00000188986 ENSMUSG00000013465 UniProt Q8WX92 Q8C4Y3 RefSeq (mRNA) NM_015456 NM_021393 NM_001310157 RefSeq (protein) NP_056271 NP_001297086 NP_067368 Location (UCSC) Chr 9: 137.26 – 137.27 Mb Chr 2: 25.09 – 25.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cofactor of BRCA1, also known as COBRA1, is a human gene that encodes NELF-B. Function NELF-B is a ...
Average mortgage rates are edging down moderately week over week of Monday, January 6, 2024, though remain at elevated levels for benchmark 30-year and 15-year fixed terms, this despite three back ...
Ternary complex of EF-Tu (blue), tRNA (red) and GTP (yellow). Taken from PDB Molecule of the Month Elongation factors, September 2006.. Elongation factors are a set of proteins that function at the ribosome, during protein synthesis, to facilitate translational elongation from the formation of the first to the last peptide bond of a growing polypeptide.