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Methylketol or 2-methylindole is a mildly toxic and slightly flammable organic compound which occurs as a white solid which turns brown over time. [1] [2] It has chemical formula C 9 H 9 N. [3] Methylketol is used as an intermediate for synthesizing dyes, [4] pigments, [5] optical brighteners, and pharmaceuticals. [6]
The Fischer indole synthesis is a chemical reaction that produces the aromatic heterocycle indole from a (substituted) phenylhydrazine and an aldehyde or ketone under acidic conditions. [19] [20] The reaction was discovered in 1883 by Hermann Emil Fischer. The Fischer indole synthesis. The choice of acid catalyst is very important.
Although the synthesis of indole itself is problematic using the Fischer indole synthesis, it is often used to generate indoles substituted in the 2- and/or 3-positions. Indole can still be synthesized, however, using the Fischer indole synthesis by reacting phenylhydrazine with pyruvic acid followed by decarboxylation of the formed indole-2 ...
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The Fischer indole synthesis is a chemical reaction that produces the aromatic heterocycle indole from a (substituted) phenylhydrazine and an aldehyde or ketone under acidic conditions. [1] [2] The reaction was discovered in 1883 by Emil Fischer. Today antimigraine drugs of the triptan class are often synthesized by this method. The Fischer ...
Indole-3-acetic acid (IAA, 3-IAA) is the most common naturally occurring plant hormone of the auxin class. It is the best known of the auxins, and has been the subject of extensive studies by plant physiologists. [ 1 ]
The reverse rate k −1 was found to increase by a factor of 53 going from cyclohexane to methanol, while the equilibrium constant K eq decreased by a factor of 140. It is suggested that there is a change of the polarity during the activation process as evidenced by correlations between the equilibrium and kinetic data.
The reaction mechanism of the Gassman indole synthesis The first step is the oxidation of the aniline 1 using tert -butyl hypochlorite (tBuOCl) to give the chloramine 2 . The second step is the addition of the keto-thioether to give the sulfonium ion 3 , and is typically done at low temperatures (−78 °C).