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  2. SN1 reaction - Wikipedia

    en.wikipedia.org/wiki/SN1_reaction

    the simple first-order rate law described in introductory textbooks. Under these conditions, the concentration of the nucleophile does not affect the rate of the reaction, and changing the nucleophile (e.g. from H 2 O to MeOH) does not affect the reaction rate, though the product is, of course, different. In this regime, the first step ...

  3. SNi - Wikipedia

    en.wikipedia.org/wiki/SNi

    This reaction type is linked to many forms of neighbouring group participation, for instance the reaction of the sulfur or nitrogen lone pair in sulfur mustard or nitrogen mustard to form the cationic intermediate. This reaction mechanism is supported by the observation that addition of pyridine to the reaction leads to inversion. The reasoning ...

  4. Nucleophilic substitution - Wikipedia

    en.wikipedia.org/wiki/Nucleophilic_substitution

    The two main mechanisms were the S N 1 reaction and the S N 2 reaction, where S stands for substitution, N stands for nucleophilic, and the number represents the kinetic order of the reaction. [4] In the S N 2 reaction, the addition of the nucleophile and the elimination of leaving group take place simultaneously (i.e. a concerted reaction).

  5. Dissociative substitution - Wikipedia

    en.wikipedia.org/wiki/Dissociative_substitution

    Dissociative pathways are characterized by a rate determining step that involves release of a ligand from the coordination sphere of the metal undergoing substitution. The concentration of the substituting nucleophile has no influence on this rate, and an intermediate of reduced coordination number can be detected.

  6. Chemical kinetics - Wikipedia

    en.wikipedia.org/wiki/Chemical_kinetics

    Chemical kinetics, also known as reaction kinetics, is the branch of physical chemistry that is concerned with understanding the rates of chemical reactions. It is different from chemical thermodynamics, which deals with the direction in which a reaction occurs but in itself tells nothing about its rate.

  7. Hammett equation - Wikipedia

    en.wikipedia.org/wiki/Hammett_equation

    The reaction constant, or sensitivity constant, ρ, describes the susceptibility of the reaction to substituents, compared to the ionization of benzoic acid. It is equivalent to the slope of the Hammett plot. Information on the reaction and the associated mechanism can be obtained based on the value obtained for ρ. If the value of:

  8. Associative substitution - Wikipedia

    en.wikipedia.org/wiki/Associative_substitution

    In many substitution reactions, well-defined intermediates are not observed, when the rate of such processes are influenced by the nature of the entering ligand, the pathway is called associative interchange, abbreviated I a. [3] Representative is the interchange of bulk and coordinated water in [V(H 2 O) 6] 2+.

  9. Ether cleavage - Wikipedia

    en.wikipedia.org/wiki/Ether_cleavage

    Ether cleavage refers to chemical substitution reactions that lead to the cleavage of ethers. Due to the high chemical stability of ethers, the cleavage of the C-O bond is uncommon in the absence of specialized reagents or under extreme conditions. [1] [2] In organic chemistry, ether cleavage is an acid catalyzed nucleophilic substitution reaction.

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