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The area provides a reference unit, for example in reference ranges for urine tests. [3]Used for grading of soft tissue tumors: Grading, usually on a scale of I to III, is based on the degree of differentiation, the average number of mitoses per high-power field, cellularity, pleomorphism, and an estimate of the extent of necrosis (presumably a reflection of rate of growth).
An elevated mitotic index indicates more cells are dividing. In cancer cells, the mitotic index may be elevated compared to normal growth of tissues or cellular repair of the site of an injury. [2] The mitotic index is therefore an important prognostic factor predicting both overall survival and response to chemotherapy in most types of cancer ...
Usually the number of mitotic figures is expressed as the total number in a defined number of high power fields, such as 10 mitoses in 10 high power fields. Since the field of vision area can vary considerably between different microscopes, the exact area of the high power fields should be defined in order to compare results from different studies.
Note: Mitotic figures are counted only at the periphery of the tumor, and counting should begin in the most mitotically active areas. Mitotic count per 10 high-power fields (HPFs) [ 21 ] Area per HPF
The grading system is based on proliferation assessed by mitotic rate and Ki-67 index and stratifies NETs into grade 1 (G1, low-grade), grade 2 (G2, intermediate-grade) and grade 3 (G3, high-grade). Tumor necrosis , although recognized as a factor associated with a potentially worse prognosis, is not included in the grading of NETs of the ...
In histopathology, the mitosis rate (mitotic count or mitotic index) is an important parameter in various types of tissue samples, for diagnosis as well as to further specify the aggressiveness of tumors. For example, there is routinely a quantification of mitotic count in breast cancer classification. [74]
The doctors and nurses didn’t believe Tomisa Starr was having trouble breathing. Two years ago, Starr, 61, of Sacramento, California, was in the hospital for a spike in her blood pressure.
Atypical carcinoid of the lung exhibiting endobronchial growth, increased mitotic activity was seen (2-10 per 10 HPF). H&E stain. Typical pulmonary carcinoid tumor. Typical pulmonary carcinoid lacks comedo-like necrosis, and has < 0.2 mitotic figures/HPF.