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An elevated mitotic index indicates more cells are dividing. In cancer cells, the mitotic index may be elevated compared to normal growth of tissues or cellular repair of the site of an injury. [2] The mitotic index is therefore an important prognostic factor predicting both overall survival and response to chemotherapy in most types of cancer ...
Cells in the mitotic phase are identified by the typical appearance of their chromosomes in the cell during the mitotic phase of the cell cycle. [4] Usually the number of mitotic figures is expressed as the total number in a defined number of high power fields, such as 10 mitoses in 10 high power fields.
Mutations in genes encoding enzymes employed in recombination cause cells to have increased sensitivity to being killed by a variety of DNA damaging agents. [90] [91] [92] These findings suggest that mitotic recombination is an adaptation for repairing DNA damages including those that are potentially lethal.
Presence of mitotic figures (an unusual number of cells which are currently dividing). [10] Other changes that occur in epithelial dysplasia include: Drop-shaped rete processes; Basal cell hyperplasia; Irregular epithelial stratification; Increased nuclear-cytoplasmic ratio; Increased normal and abnormal mitosis; Enlarged nucleoli; Individual ...
Atypical carcinoid of the lung exhibiting endobronchial growth, increased mitotic activity was seen (2-10 per 10 HPF). H&E stain. Typical pulmonary carcinoid tumor. Typical pulmonary carcinoid lacks comedo-like necrosis, and has < 0.2 mitotic figures/HPF.
Mitotic cell rounding is a shape change that occurs in most animal cells that undergo mitosis. Cells abandon the spread or elongated shape characteristic of interphase and contract into a spherical morphology during mitosis.
Mitotic trigger waves are waves of Cyclin-dependent kinase 1 activity in cells that originate from pacemaker regions of the nucleus and propagate through the cytoplasm. [1]. Because trigger waves do not decrease in speed or amplitude during their propagation, they are more reliable at conveying molecular information across greater distances ...
Higher grade tumors are anaplastic, show signs of increased vessel density, elevated mitotic activity, and higher cellular density. Glioblastoma is a specific grade IV astrocytoma, showing vascular endothelial proliferation necrosis and very high cell density and atypias.