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  2. Pantoprazole - Wikipedia

    en.wikipedia.org/wiki/Pantoprazole

    The pharmacokinetics of pantoprazole have been explored in several veterinary species, including calves, alpacas and foals with half lives reported as 2.81, 0.47, and 1.43 hours, respectively. [ 40 ] [ 41 ] [ 42 ] Pantoprazole appears to be eliminated more quickly in goats when compared to calves, with goats having an elimination half-life of ...

  3. Discovery and development of proton pump inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Most oral PPI preparations are enteric-coated, due to the rapid degradation of the drugs in the acidic conditions of the stomach. For example omeprazole is unstable in acid with a half-life of 2 min at pH 1–3, but is significantly more stable at pH 7 (half-life ca. 20 h).

  4. Half-life - Wikipedia

    en.wikipedia.org/wiki/Half-life

    In this situation it is generally uncommon to talk about half-life in the first place, but sometimes people will describe the decay in terms of its "first half-life", "second half-life", etc., where the first half-life is defined as the time required for decay from the initial value to 50%, the second half-life is from 50% to 25%, and so on.

  5. Proton-pump inhibitor - Wikipedia

    en.wikipedia.org/wiki/Proton-pump_inhibitor

    In healthy humans, the half-life of PPIs is about 1 hour (9 hours for tenatoprazole), but the duration of acid inhibition is 48 hours because of irreversible binding to the H,K-ATPase. [82] All the PPIs except tenatoprazole are rapidly metabolized in the liver by CYP enzymes (mostly by CYP2C19 and 3A4). [ 82 ]

  6. List of radioactive nuclides by half-life - Wikipedia

    en.wikipedia.org/wiki/List_of_radioactive...

    Radioactive isotope table "lists ALL radioactive nuclei with a half-life greater than 1000 years", incorporated in the list above. The NUBASE2020 evaluation of nuclear physics properties F.G. Kondev et al. 2021 Chinese Phys. C 45 030001. The PDF of this article lists the half-lives of all known radioactives nuclides.

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  8. FDA approves opioid-free pain medication with 'no sign of ...

    www.aol.com/news/fda-approves-opioid-free-pain...

    A new opioid-free pain medication was approved by the U.S. Food and Drug Administration (FDA) on Thursday, marking a non-addictive alternative for patients. Journavx (suzetrigine), made by Vertex ...

  9. FDA approves new pain medication as an alternative to opioids ...

    www.aol.com/fda-approves-pain-medication...

    The FDA on Thursday approved a new class of pain medication that provides an alternative to opioids. It will be sold under the brand name Journavx.

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