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The particular PEGylated molecule in the Moderna vaccine is known as DMG-PEG 2000. Pegvaliase (Biomarin) – PEGylated recombinant phenylalanine ammonia-lyase for the treatment of Phenylketonuria, approved by the FDA for the US in May 2018. [22] [23] Adynovate – PEGylated Antihemophilic Factor VIII for the treatment of patients with hemophilia A.
Pegylated interferon alfa-2b is a drug used to treat melanoma, as an adjuvant therapy to surgery. [3] Also used to treat hepatitis C (typically, in combination with ribavarin), it is no longer recommended due to poor efficacy and adverse side-effects. [4] Subcutaneous injection is the preferred delivery method. [3]
Pegylated interferon alfa-2a is in the alpha interferon family of medications. [3] It is pegylated to protect the molecule from breakdown. [6] Pegylated interferon alfa-2a was approved for medical use in the United States in 2002. [3] It is on the World Health Organization's List of Essential Medicines. [7]
Pegylated interferon-alpha-2b; Pegylated interferon beta-1a [2] In these formulations, Polyethylene glycol (PEG) is added to make interferon last longer in the body. [3] They are used to treat both hepatitis B, [4] hepatitis C [1] and multiple sclerosis. [2] Pegylated interferon is contraindicated in patients with hyperbilirubinaemia. [citation ...
Pegipanermin (USAN Tooltip United States Adopted Name; developmental code names and proposed brand names DN-TNF, INB-03, LIVNate, Quellor XENP345, XPro1595) is a tumor necrosis factor α (TNFα) inhibitor which is under development for the treatment of Alzheimer's disease, mild cognitive impairment, major depressive disorder, and other indications.
Halozyme Therapeutics, Inc. is an American biotechnology company. It develops oncology therapies designed to target the tumor microenvironment . The company was founded in 1998 and went public in 2004.
Pegaptanib is a pegylated anti-vascular endothelial growth factor (VEGF) aptamer, a single strand of nucleic acid that binds with specificity to a particular target. . Pegaptanib specifically binds to the 165 isoform of VEGF, a protein that plays a critical role in angiogenesis (the formation of new blood vessels) and increased permeability (leakage from blood vessels), two of the primary ...
It can be useful to improve bioavailability and extend the half-life of various therapeutic proteins. [2] [1] [3] Examples of glycopegylated molecules include pegozafermin [4] and recombinant factor IX. [5]