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Niemann–Pick disease (NP), also known as acid sphingomyelinase deficiency, is a group of rare genetic diseases of varying severity.These are inherited metabolic disorders in which sphingomyelin accumulates in lysosomes in cells of many organs.
The lysosomal storage disorders Niemann-Pick disease, SMPD1-associated (type A and B) are characterized by deficiencies in acid sphingomyelinase. [3] Diagnosis is confirmed by an aSMase activity less than 10% in the peripheral blood lymphocytes. [citation needed] Caused by a mutation in the SMPD1 gene, it is found in 1:250,000 in the population.
Sphingolipidoses are a class of lipid storage disorders or degenerative storage disorders caused by deficiency of an enzyme that is required for the catabolism of lipids that contain ceramide, [1] also relating to sphingolipid metabolism.
One of the possible causes of food allergies in dogs is a reaction of the dog's immune system to the proteins in a diet. [12] One method that may be used to try and combat this immunologic response in dogs with food allergies is the use of hydrolyzed proteins in the diet.
Dogs are prone to have adverse allergic reactions to food similar to human beings. The most common symptoms of food allergies in dogs include rashes, swelling, itchy or tender skin, and gastrointestinal upsets such as uncontrollable bowel movements and soft stools. [82] Certain ingredients in dog food can elicit these allergic reactions.
Acid sphingomyelinase deficiency is seriously debilitating and life-threatening since the build-up of fatty substances can cause brain damage and swelling of organs such as liver and spleen. [ 5 ] Xenpozyme is the first acid sphingomyelinase deficiency-specific treatment. [ 5 ]
Here's a breakdown of the key foods that should form the foundation of a Wegovy diet plan: Fruits and vegetables They're packed with important vitamins, minerals, and fiber.
Food allergy* in dogs is commonly manifested as itching, especially of the face, paws, and the underside. Skin testing has proved unreliable, and a trial of a hypoallergenic diet is usually used for diagnosis. [82] Follicular dysplasia is a genetic disease of dogs causing alopecia, or hair loss. It is caused by hair follicles that are ...