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The clinical development program for NV-5138 began with a Phase 1 trial initiated by Navitor Pharmaceuticals in 2018. [1] [7] This initial study was designed to evaluate the safety, tolerability, and pharmacokinetics of the compound in both healthy volunteers and patients diagnosed with TRD. [8] Following the Phase 1 trial,larger Phase 2 ...
A new slow-release tablet form of ketamine, which can be safely taken at home, could help treat severe depression, according to a clinical trial. At-home ketamine tablet may alleviate symptoms of ...
A new study compares ketamine with electroconvulsive therapy in people with treatment-resistant depression. The researchers identify subsets of people who respond better to ketamine and vice versa.
Ketamine-assisted psychotherapy (KAP) is the use of prescribed doses of ketamine as an adjunct to psychotherapy sessions. KAP shows significant potential in treating mental disorders such as treatment-resistant depression (TRD), anxiety, obsessive–compulsive disorders (OCD), post-traumatic stress disorders (PTSD), and other conditions. [1]
Ketamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a treatment for depression and in pain management. [19] Ketamine is an NMDA receptor antagonist which accounts for most of its psychoactive effects. [20]
Similar research has shown that clinical trials of psilocybin have “produced promising results concerning the treatment of addiction, depression and end-of-life mood disorders,” according to ...
Ketamine can quickly ease depression and soothe suicidal thoughts in the short term, research has revealed. Analysis of 83 research papers showed that patients’ symptoms were reduced in just one ...
Research into the use of ketamine to treat MDD had already determined that the drug could have effectiveness in rapidly reducing the symptoms of depression. [13] Unfortunately ketamine has powerful dissociative effects, leaving patients in a trance-like state after administration and lending itself to recreational abuse.
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