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Bacitracin/polymyxin B (trade name Polysporin among others) is a topical antibiotic cream or ointment. [1] The active ingredients are polymyxin B , bacitracin and occasionally garamycin or gramicidin .
A variant of Polysporin, called Polysporin Triple Ointment, replaces neomycin with gramicidin, providing an alternative for those allergic to neomycin while still offering broad-spectrum coverage against both Gram-negative and Gram-positive bacteria.
Polymyxin B, sold under the brand name Poly-Rx among others, is an antibiotic used to treat meningitis, pneumonia, sepsis, and urinary tract infections. [1] While it is useful for many Gram negative infections, it is not useful for Gram positive infections. [1]
Polymyxin antibiotics are relatively neurotoxic and nephrotoxic, so are usually used only as a last resort if modern antibiotics are ineffective or are contraindicated. . Typical uses are for infections caused by strains of multiple drug-resistant Pseudomonas aeruginosa or carbapenemase-producing Enterobacteri
Common allergens implicated include the following: Bacitracin – topical antibiotic found by itself, or as Polysporin or Triple Antibiotic; Balsam of Peru (Myroxylon pereirae) – used in food and drink for flavoring, in perfumes and toiletries for fragrance, and in medicine and pharmaceutical items for healing properties; derived from tree resin.
Physicians sometimes recommend using antibiotic ointments without neomycin, such as Polysporin. [11] The following represents minimum inhibitory concentration (MIC) susceptibility data for a few medically significant Gram-negative bacteria. [12] Enterobacter cloacae: >16 μg/ml; Escherichia coli: 1 μg/ml; Proteus vulgaris: 0.25 μg/ml
Sahay Ram Bose (Bengali: সহায়রাম বসু; 15 February 1888 – 1970) was an Indian botanist. [1] He was known for his pioneering work in the study of bracket fungi and the discovery of antibiotics Polysporin and Campestrin.
Human papillomavirus infection (HPV infection) is caused by a DNA virus from the Papillomaviridae family. [5] Many HPV infections cause no symptoms and 90% resolve spontaneously within two years. [1]
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