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Typhoid fever, also known simply as typhoid, is a disease caused by Salmonella enterica serotype Typhi bacteria, also called Salmonella Typhi. [2] [3] Symptoms vary from mild to severe, and usually begin six to 30 days after exposure. [4] [5] Often there is a gradual onset of a high fever over several days. [4]
The chlorination of public drinking water led to the sharp reduction of typhoid in developed nations. [8] In typhoid-endemic countries, Typhoid vaccines have been shown to prevent 40 to 90% of cases during the first two years, [ 9 ] and may have some effect for up to seven years.
During the American Civil War, 81,360 Union soldiers died of typhoid or dysentery, far more than died of battle wounds. [25] In the late 19th century, the typhoid fever mortality rate in Chicago averaged 65 per 100,000 people a year. The worst year was 1891, when the typhoid death rate was 174 per 100,000 people. [26]
Typhoid fever is caused by the bacterium Salmonella enterica Serovar Typhi. [ 37 ] In Canada alone, the typhus epidemic of 1847 killed more than 20,000 people from 1847 to 1848, mainly Irish immigrants in fever sheds and other forms of quarantine, who had contracted the disease aboard the crowded coffin ships in fleeing the Great Irish Famine .
The medical officer stopped keeping a record of the deaths after early October 1897 so more people may have died. The epidemic was a ‘...turning point in public health...’; during the epidemic trials of water sterilisation using chlorination and the first immunisations with typhoid vaccine were carried out in Maidstone. [3]
In 1964, there was an outbreak of typhoid in the city of Aberdeen, Scotland.The first two cases were identified on 20 May 1964; eventually over 400 cases were diagnosed and the patients were quarantined at the City Hospital in Urquhart Road, Woodend Hospital in Eday Road, and Tor-na-Dee Hospital in Milltimber which was used as an overflow hospital for typhoid cases. [1]
The 1937 Croydon typhoid outbreak, also known as the Croydon epidemic of typhoid fever, [1] was an outbreak of typhoid fever in Croydon, Surrey, now part of London, in 1937. It resulted in 341 cases of typhoid (43 fatal), and it caused considerable local discontent leading to a media campaign and a public inquiry.
Typhoid vaccines are vaccines that prevent typhoid fever. [1] [2] [3] Several types are widely available: typhoid conjugate vaccine (TCV), Ty21a (a live oral vaccine) and Vi capsular polysaccharide vaccine (ViPS) (an injectable subunit vaccine). They are about 30 to 70% effective in the first two years, depending on the specific vaccine in ...