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Timing is important to wound healing. Critically, the timing of wound re-epithelialization can decide the outcome of the healing. [11] If the epithelization of tissue over a denuded area is slow, a scar will form over many weeks, or months; [12] [13] If the epithelization of a wounded area is fast, the healing will result in regeneration.
Ecchymoses also have a more diffuse border than other purpura. [14] A broader definition of ecchymosis is the escape of blood into the tissues from ruptured blood vessels. [ 15 ] [ 16 ] The term also applies to the subcutaneous discoloration resulting from seepage of blood within the injured tissue.
Bleeding, hemorrhage, haemorrhage or blood loss is blood escaping from the circulatory system from damaged blood vessels. [1] Bleeding can occur internally, or externally either through a natural opening such as the mouth, nose, ear, urethra, vagina or anus, or through a puncture in the skin.
Research into hormones and wound healing has shown estrogen to speed wound healing in elderly humans and in animals that have had their ovaries removed, possibly by preventing excess neutrophils from entering the wound and releasing elastase. [26] Thus the use of estrogen is a future possibility for treating chronic wounds.
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A wound is any disruption of or damage to living tissue, such as skin, mucous membranes, or organs. [1] [2] Wounds can either be the sudden result of direct trauma (mechanical, thermal, chemical), or can develop slowly over time due to underlying disease processes such as diabetes mellitus, venous/arterial insufficiency, or immunologic disease. [3]
Terlipressin appears to be more effective than octreotide, but it is not available in many areas of the world. [16] [30] It is the only medication that has been shown to reduce mortality in acute variceal bleeding. [30] This is in addition to endoscopic banding or sclerotherapy for the varices. [13]
Wounds naturally heal by themselves, but hunter-gatherers would have noticed several factors and certain herbal remedies would speed up or assist the process, especially if it was grievous. In ancient history , this was followed by the realisation of the necessity of hygiene and the halting of bleeding , where wound dressing techniques and ...