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Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Phosphodiesterase-5. A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).
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ED medications aren’t magic, and a healthcare professional will explain that phosphodiesterase type 5 inhibitors aren’t growth hormones, nor do they treat finishing early or psychological ED.
Drug interactions that may come from taking Cialis with other medications. ... Indigestion is a common side effect of most oral ED medications, which are known as phosphodiesterase 5 inhibitors ...
From your mental state to your eating habits, a range of factors can and will influence the effectiveness of Viagra and other phosphodiesterase type 5 inhibitors like Cialis and Stendra.
These drugs came out of research programs focusing on finding PDE5 inhibitors for the treatment of cardiovascular diseases and erectile dysfunction. The two PDE5 inhibitors soon became treatments for these conditions. [22] [23] Tadalafil is the most versatile inhibitor and has the longest half-life, 17.5 hours.
This is thanks to an enzyme called phosphodiesterase type 5 (PDE5). Viagra inhibits PDE5 and acts as a vasodilator (something that dilates blood vessels and increases blood flow).