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Salmon calcitonin (sCT) [1] is the type of calcitonin hormone found in salmon. [ 2 ] Similar to humans, salmon calcitonin is a peptide hormone produced in the ultimobranchial region by parafollicular cells in response to hypercalcemia and lowers blood calcium and phosphate by promoting renal excretion.
Calcitonin has clinically been used for metabolic bone disorders for more than 50 years. [25] Salmon calcitonin is used for the treatment of: Postmenopausal osteoporosis [26] Hypercalcaemia [27] Bone metastases [28] Paget's disease [29] Phantom limb pain [30] It has been investigated as a possible non-operative treatment for spinal stenosis. [31]
The same 45-year-old man with diabetes mellitus presented with a diffusely swollen, warm and non-tender left foot due to Charcot arthropathy. There are no changes to the skin itself. The clinical presentation varies depending on the stage of the disease from mild swelling to severe swelling and moderate deformity.
The salmon’s plight is fueled by the toxic politics of California water, with one stakeholder blaming another. It takes so many human mistakes to kill off this species. And we’re so darn close.
Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of drugs that act as antagonists of the calcitonin gene-related peptide receptor (CGRPR). [ 1 ] Several monoclonal antibodies that bind to the CGRP receptor or peptide have been approved for prevention of migraine. [ 2 ]
The devastation caused by wildfires extends far beyond human homes. Northern California’s Park Fire has burned through some of the Central Valley’s last wild salmon habitat, dealing a blow to ...
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Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides consisting of calcitonin, amylin, adrenomedullin, adrenomedullin 2 and calcitonin‑receptor‑stimulating peptide. Calcitonin is mainly produced by thyroid C cells whilst CGRP is secreted and stored in the nervous system. [1]