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Zaleplon, sold under the brand name Sonata among others, is a sedative and hypnotic which is used to treat insomnia. It is a nonbenzodiazepine or Z-drug of the pyrazolopyrimidine class. [ 10 ] It was developed by King Pharmaceuticals and approved for medical use in the United States in 1999.
Zolpidem and zaleplon are, in the US, indicated for 7-10 days of use only. Longer periods of use lead to loss of efficacy from tolerance. [18] Tolerance has also been demonstrated with zopiclone, [19] which is indicated for a maximum of 4 weeks of use in New Zealand. [20]
High dose misuse of zopiclone and increasing popularity amongst people who use substances who have been prescribed with zopiclone [83] [clarification needed] The symptoms of zopiclone addiction can include depression, dysphoria, hopelessness, slow thoughts, social isolation, worrying, sexual anhedonia, and nervousness.
While the 500 mg and 750 mg strength capsules were for use in reducing sleep latency, the 200 mg strength capsules were intended to be used to re-induce sleep in case of early awakening. Abbott discontinued production in 1999, due to it being replaced by the benzodiazepine family and its widespread abuse, [ 2 ] after which Placidyl was ...
"Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. Benzodiazepines generally share the same pharmacological properties, such as anxiolytic, sedative, hypnotic, skeletal muscle relaxant, amnesic, and anticonvulsant effects. Variation in potency of certain effects may exist amongst individual ...
The medication is designed to increase dosage over a period of time with a maximum dosage of 15 milligrams, according to the FDA. “These drugs are super powerful. They’re also super expensive ...
The study found that at these doses which are two or more times greater than the maximum recommended doses, a dose-related increase in reports of amnesia, sedation, sleepiness, and hallucinations was observed for both eszopiclone (Lunesta) as well as for diazepam . [21]
A typical starting dosage is 200 mg per day, taken twice a day in 100 mg doses. The maximum Wellbutrin dosage is 450 mg. Wellbutrin XL is the extended-release version, ranging between 150 mg and ...