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Myosin light-chain kinase also known as MYLK or MLCK is a serine/threonine-specific protein kinase that phosphorylates a specific myosin light chain, namely, the regulatory light chain of myosin II. [ 3 ]
MLC kinase phosphorylates the myosin light chain (MLC 20) at the Ser-19 residue. This phosphorylation causes a conformational change in the myosin, activating crossbridge cycling and causing the muscle to contract. Because myosin undergoes a conformational change, the muscle will stay contracted even if calcium and activated MLC kinase ...
Myosin light chain kinase (MLCK) inhibitors are one of the few peptides that can cross the plasma membrane relatively quickly. Under stressful conditions, MLCK's in the human body promotes increased permeability of microvessels. It is thought that MLCK phosphorylates endothelial myosin, leading to cell contraction.
This gene, a muscle member of the immunoglobulin superfamily, encodes a myosin light-chain kinase, which is a calcium-/calmodulin-dependent enzyme.This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity.
Telokin have two related functions in the C-terminal myosin-binding domain of smooth muscle myosin light chain kinase (MLCK). First, telokin stabilizes myosin filaments in the presence of ATP. Second, telokin can modulate the level of myosin light chain phosphorylation. In this latter role, multiple mechanisms have been suggested.
Myosin light chain kinase 4 also known as MYLK4 is an enzyme which in humans is encoded by the MYLK2 gene. [2] MYLK4 is a member of the myosin light-chain kinase family of serine/threonine-specific protein kinases that phosphorylate the regulatory light chain of myosin II .
Specialized CaM kinases, such as the myosin light chain kinase that phosphorylates myosin, causing smooth muscles to contract. Multifunctional CaM kinases, also collectively called CaM kinase II, which play a role in neurotransmitter secretion, transcription factor regulation, and glycogen metabolism.
213435 Ensembl ENSG00000140795 ENSMUSG00000031698 UniProt Q32MK0 Q3UIZ8 RefSeq (mRNA) NM_001308301 NM_182493 NM_001297612 NM_175441 RefSeq (protein) NP_001295230 NP_872299 NP_001284541 NP_780650 Location (UCSC) Chr 16: 46.7 – 46.79 Mb Chr 8: 86.05 – 86.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans ...