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In a 2023 review of research on supplementation with NAD-boosting compounds, researchers found that the supplements were safe and tolerable in healthy, middle-aged and older adults.
A 2009 review of longevity research noted: "Extrapolation from worms to mammals is risky at best, and it cannot be assumed that interventions will result in comparable life extension factors. Longevity gains from dietary restriction, or from mutations studied previously, yield smaller benefits to Drosophila than to nematodes, and smaller still ...
A new study explains how mitochondria act as “reservoirs” to store NAD for cells to use, which could help scientists come up with NAD-boosting therapies to combat aging and age-related diseases.
The intracellular half-life of NAD + was claimed to be between 1–2 hours by one review, [24] whereas another review gave varying estimates based on compartment: intracellular 1–4 hours, cytoplasmic 2 hours, and mitochondrial 4–6 hours. [25]
"The first 1000-year-old is probably only ~10 years younger than the first 150-year-old."–Aubrey de Grey, 2005 [1]. In the life extension movement, longevity escape velocity (LEV), actuarial escape velocity [2] or biological escape velocity [3] is a hypothetical situation in which one's remaining life expectancy (not life expectancy at birth) is extended longer than the time that is passing.
Life Extension: A Practical Scientific Approach is a 1982 book (ISBN 0-446-51229-X) by Durk Pearson and Sandy Shaw that popularized the life extension and smart drug movements. [ 1 ] [ 2 ] The authors promotes the theory that free radicals are a primary cause of aging and recommended antioxidant supplements to prevent the damage they supposedly ...
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