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1-Phenylethylamine (1-PEA or α-PEA), also known as α-methylbenzylamine, is the organic compound with the formula C 6 H 5 CH(NH 2)CH 3. This primary amine is a colorless liquid is often used in chiral resolutions. Like benzylamine, it is relatively basic and forms stable ammonium salts and imines.
Benzylamine is used as a masked source of ammonia, since after N-alkylation, the benzyl group can be removed by hydrogenolysis: [10] C 6 H 5 CH 2 NH 2 + 2 RBr → C 6 H 5 CH 2 NR 2 + 2 HBr C 6 H 5 CH 2 NR 2 + H 2 → C 6 H 5 CH 3 + R 2 NH. Typically a base is employed in the first step to absorb the HBr (or related acid for other kinds of ...
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lic 6 h 4 ch 2 n(ch 3) 2 + e + → 2-ec 6 h 4 ch 2 n(ch 3) 2 Via these reactions, many derivatives are known with the formula 2-X-C 6 H 4 CH 2 N(CH 3 ) 2 (E = SR, PR 2 , etc.). The amine is basic and undergoes quaternization with alkyl halides (e.g. hexyl bromide ) to give quaternary ammonium salts: [ 4 ]
N-Methylphenethylamine (NMPEA) is a naturally occurring trace amine neuromodulator in humans that is derived from the trace amine, phenethylamine (PEA). [2] [3] It has been detected in human urine (<1 μg over 24 hours) [4] and is produced by phenylethanolamine N-methyltransferase with phenethylamine as a substrate, which significantly increases PEA's effects.
It is the N-benzyl derivative of 3,4-methylenedioxyamphetamine (MDA). MDBZ was first synthesized by Alexander Shulgin . In his book PiHKAL (Phenethylamines i Have Known And Loved) , the minimum dosage is listed as 150 mg, and the duration unknown.
Dogs need to be able to chew because it's one of their natural instincts, so it's important to let them chew on the right things and not the couch, shoes, or anything else they're not supposed to.
While in-vitro studies showed that N-benzyl derivatives of 2C-I were significantly increased in potency compared to 2C-I, the N-benzyl derivatives of the related compound DOI were inactive. [60] 25B-NBOMe is a low-potency weak partial agonist of the rat and mouse trace amine-associated receptor 1 (TAAR1) but is inactive at the human TAAR1. [61]
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