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When methenamine was first introduced in the late 1800s and early 1900s, doses of 15 to 30 g per day were commonly employed and doses of up to 60 to 180 g per day were tried in some cases. [42] Toxic effects of such high doses included urinary tract and bladder irritation, frequent urination, strangury , and hematuria. [ 42 ]
A urinary tract infection ... percent per day and prophylactic ... is an oral 3g dose administered once every 48 or 72 hours for a total of 3 doses or a 6 grams every ...
[15] [25] Treatment with nitrofurantoin for 7 days was not more effective than treatment for 5 days, whereas treatment for 5 days was superior to treatment for 3 days (which showed clinical cure rates of 61–70%). [15] [25] [21] The effectiveness of nitrofurantoin for 5 days is equivalent to that with single-dose fosfomycin. [26]
The Pauling's book How to Live Longer and Feel Better, [92] first published in 1986, [93] was a bestseller and advocated taking more than 10 grams per day orally, thus approaching the amounts released by the liver directly into the circulation in other mammals: an adult goat, a typical example of a vitamin C–producing animal, will manufacture ...
Fosfomycin can be used as an efficacious treatment for both UTIs and complicated UTIs including acute pyelonephritis. The standard regimen for complicated UTIs is an oral 3 g dose administered once every 48 or 72 hours for a total of 3 doses or a 6 g dose every 8 hours for 7–14 days when fosfomycin is given in IV form.
Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cephalexin, and is used similarly in the treatment of mild to moderate susceptible infections such as the bacterium Streptococcus pyogenes, causing the disease popularly called strep throat or streptococcal tonsillitis, urinary tract infection, reproductive tract infection, and skin infections.
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