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Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein -related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.
The 4Kscore combines total, free, and intact PSA with human kallikrein 2. [46] It is used to try to determine the risk of a Gleason score greater than 6. [46] The Prostate Health Index (PHI) is a PSA-based blood test for early prostate cancer screening. It may be used to determine when a biopsy is needed.
PSA levels between 4 and 10 suggest you could have about a 25 percent chance of prostate cancer, and levels over 10 signal that your chance of having the cancer is more than 50 percent.
PSA is a protein that’s produced by prostate tissue, according to the Mayo Clinic. The test can detect high levels of PSA, which might signal prostate cancer. High PSA could also suggest other ...
Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder.Abnormal growth of the prostate tissue is usually detected through screening tests, typically blood tests that check for prostate-specific antigen (PSA) levels.
A more refined prognosis can be established by consideration of prostate-specific antigen, and grade (i.e. Gleason score in the Gleason grading system). For example, it is common to classify patients into high, intermediate and low-risk groups on the basis of these three factors (TNM stage, PSA and Gleason score).
Gleason scores range from 2 to 10, with 2 representing the most well-differentiated tumors and 10 the least-differentiated tumors. Gleason scores have often been categorized into groups that show similar biologic behavior: low-grade (well-differentiated), intermediate-grade, moderate to poorly differentiated or high-grade.
56318 Ensembl ENSG00000014257 ENSMUSG00000032561 UniProt P15309 Q8CE08 RefSeq (mRNA) NM_001099 NM_001134194 NM_001292037 NM_019807 NM_207668 RefSeq (protein) NP_001090 NP_001127666 NP_001278966 NP_062781 NP_997551 Location (UCSC) Chr 3: 132.32 – 132.37 Mb Chr 9: 104.17 – 104.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Prostatic acid phosphatase (PAP), also prostatic ...
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