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Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. [ 4 ] [ 5 ] It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. [ 6 ]
This layer is the main site for production of aldosterone, a mineralocorticoid, by the action of the enzyme aldosterone synthase. [16] [17] Aldosterone plays an important role in the long-term regulation of blood pressure. [18]
The outermost layer, the zona glomerulosa is the main site for the production of aldosterone, a mineralocorticoid. The synthesis and secretion of aldosterone are mainly regulated by the renin–angiotensin–aldosterone system. The zona glomerulosa cells express a specific enzyme aldosterone synthase (also known as CYP11B2).
Conn's Syndrome, also known as primary aldosteronism, is a condition that causes high blood pressure due to excessive production of the hormone aldosterone by the adrenal glands.
Aldosterone: mineralocorticoid: adrenal cortex (zona glomerulosa) MR: Increase blood volume by reabsorption of sodium in kidneys (primarily) Potassium and H + secretion in kidney. Estradiol: estrogen: E 2: females: ovary, males testes: females: granulosa cells, males: Sertoli cell: ER: Females: Structural: promote formation of female secondary ...
Cortisol, corticosterone, aldosterone are produced in the adrenal cortex. [ 25 ] [ 74 ] Estradiol, estrone and progesterone are made primarily in the ovary , estriol in placenta during pregnancy, and testosterone primarily in the testes [ 25 ] [ 77 ] [ 78 ] [ 79 ] (some testosterone may also be produced in the adrenal cortex).
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones.Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism ...
The opposite mechanism is called transrepression. The hormone receptor without ligand binding interacts with heat shock proteins and prevents the transcription of targeted genes. Aldosterone and cortisol (a glucosteroid ) have similar affinity for the mineralocorticoid receptor; however, glucocorticoids circulate at roughly 100 times the level ...