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Cerebral perfusion pressure, or CPP, is the net pressure gradient causing cerebral blood flow to the brain (brain perfusion).It must be maintained within narrow limits because too little pressure could cause brain tissue to become ischemic (having inadequate blood flow), and too much could raise intracranial pressure (ICP).
Traumatic brain injury can cause dangerously raised intracranial pressure. Pressure reactivity index or PRx is a tool for monitoring cerebral autoregulation in the intensive care setting for patients with severe traumatic brain injury or subarachnoid haemorrhage, in order to guide therapy to protect the brain from dangerously high or low cerebral blood flow.
Because CPP is measured by the difference in aortic and LVEDP pressures, an increase in LVEDP will decrease CPP. The heart may compensate for this reduction in CPP by increasing contractility and subsequent aortic pressure. However, this process requires greater oxygen consumption and will promote ventricular remodeling. While this process may ...
Cerebral perfusion pressure (CPP), the pressure of blood flowing to the brain, is normally fairly constant due to autoregulation, but for abnormal mean arterial pressure (MAP) or abnormal ICP the cerebral perfusion pressure is calculated by subtracting the intracranial pressure from the mean arterial pressure: CPP = MAP − ICP .
A medical calculator is a type of medical computer software, whose purpose is to allow easy calculation of various scores and indices, presenting the user with a friendly interface that hides the complexity of the formulas. Most offer further information such as result interpretation guides and medical literature references. [1]
MDCalc is a free online medical reference for healthcare professionals that provides point-of-care clinical decision-support tools, including medical calculators, scoring systems, and algorithms. [1] MDCalc is also a mobile and web app. [ 2 ] The decision-support tools are based on published clinical research, [ 3 ] and MDCalc’s content is ...
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The Fick principle states that blood flow to an organ can be calculated using a marker substance if the following information is known: . Amount of marker substance taken up by the organ per unit time