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We randomly assigned 614 patients with permanent atrial fibrillation to undergo a lenient rate-control strategy (resting heart rate <110 beats per minute) or a strict rate-control strategy...
The results of this trial indicate that a lenient rate control strategy, with a target resting HR <110 bpm is easier to achieve with beta-blockers, calcium-channel blockers, and/or digoxin, as compared with a strict control strategy, with a target resting HR <80 bpm, and an exercise HR <110 bpm.
The RACE II Study On the basis of these data, the RACE II study was performed to prospectively compare strict versus lenient rate control strategies for patients with AF. In RACE II, 614 patients with permanent AF were randomly assigned to lenient (resting heart rate <110 bpm) or strict (resting heart rate <80 bpm and heart rate during moderate ...
The current analysis compares cardiovascular morbidity, mortality, and quality-of-life endpoints in those with lenient rate control with those that achieved and failed to achieve strict rate control at the end of the dose-adjustment phase in the original RACE II study.
The first, and as yet the only, study to prospectively investigate the effect of different rate-control strategies on outcome is the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation: a comparison between Lenient and Strict Rate Control II) study.
RACE-II TRIAL; Problem: Atrial fibrillation: Format-Treatment: Lenient rate control (HR<110) Control: Strict rate control (HR<80) Population: 614 patients: Inclusion criteria: Permanent atrial fibrillation for up to 12 months Age of 80 years or younger Mean resting heart rate above 80 beats per minute
We hypothesized that lenient rate control is not inferior to strict rate control for preventing cardiovascular morbidity and mortality in patients with permanent atrial fibrillation.
This analysis of the RACE II study shows no difference in cardiovascular outcome between successful strict, failed strict, and lenient rate control in patients with permanent AF. In addition, quality of life was comparable between the groups at the end of follow-up.
Methods: The RACE II study is a prospective multicenter trial in The Netherlands that will randomize 500 patients with permanent AF (< or = 12 months) to strict or lenient rate control. Strict rate control is defined as a mean resting heart rate < 80 beats per minute (bpm) and heart rate during minor exercise < 110 bpm.
RACE II (Rate Control Efficacy in Perma-nent Atrial Fibrillation: a Comparison be-tween Lenient versus Strict Rate Control II) study are listed in the Appendix.