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Long QT syndrome (LQTS) is a condition affecting repolarization (relaxing) of the heart after a heartbeat, giving rise to an abnormally lengthy QT interval. [7] It results in an increased risk of an irregular heartbeat which can result in fainting, drowning, seizures, or sudden death. [1] These episodes can be triggered by exercise or stress. [6]
This type of connective tissue is found mostly in the reticular layer (or deep layer) of the dermis. [3] It is also in the sclera and in the deeper skin layers. Due to high portions of collagenous fibers, dense irregular connective tissue provides strength, making the skin resistant to tearing by stretching forces from different directions. [4]
Coronary artery disease (CAD), also called coronary heart disease (CHD), or ischemic heart disease (IHD), [13] is a type of heart disease involving the reduction of blood flow to the cardiac muscle due to a build-up of atheromatous plaque in the arteries of the heart. [5] [6] [14] It is the most common of the cardiovascular diseases. [15]
As the disease worsens, shortness of breath, feeling tired, and swelling of the legs may occur, due to the onset of heart failure. [1] An irregular heart beat and fainting may occur. [1] Those affected are at an increased risk of sudden cardiac death. [2] As of 2013, cardiomyopathies are defined as "disorders characterized by morphologically ...
Fibrosis can be a normal connective tissue deposition or excessive tissue deposition caused by a disease. [ 2 ] Repeated injuries, chronic inflammation and repair are susceptible to fibrosis, where an accidental excessive accumulation of extracellular matrix components, such as the collagen, is produced by fibroblasts, leading to the formation ...
The age at disease onset of HCM with MYH7 is earlier and leads to more severe symptoms. [30] Moreover, mutations on troponin C can alter Ca +2 sensibility on force development in cardiac muscle, these mutations are named after the amino acid that was changed after the location in which it happened, such as A8V, A31S, C84Y and D145E. [31]
The disease is a type of non-ischemic cardiomyopathy that primarily involves the right ventricle, though cases of exclusive left ventricular disease have been reported. It is characterized by hypokinetic areas involving the free wall of the ventricle, with fibrofatty replacement of the myocardium, with associated arrhythmias often originating ...
Eisenmenger syndrome or Eisenmenger's syndrome is defined as the process in which a long-standing left-to-right cardiac shunt caused by a congenital heart defect (typically by a ventricular septal defect, atrial septal defect, or less commonly, patent ductus arteriosus) causes pulmonary hypertension [1] [2] and eventual reversal of the shunt into a cyanotic right-to-left shunt.
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