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It is clinically characterized by severe osteoporosis which is usually recognized and posteriorly diagnosed in early childhood. This usually leads to various complications, the primary one being recurrent bone fractures. [1] [2] Another very common symptom is total blindness, which usually manifests in two ways:
Abdominal pain or diarrhea or both 3 Sicca-like symptoms 4 Pericarditis or pleuritis or both Molecular Criterion: NOD2 IVS8+158 or R702W or both, or other rare variants Exclusion Criteria: High titer antinuclear antibodies, inflammatory bowel disease, Blau syndrome, adult sarcoidosis, primary Sjögren syndrome and monogenic autoinflammatory ...
Osteoporosis is a very prevalent disease in the elderly population but not much is known about the optimal prescription and dosage of physical exercise to help prevent bone mineral loss. A lot of the focus around osteoporosis is also prevention and not so much maintenance which should be the front runner when considering what approach to take.
Senile osteoporosis has been recently recognized as a geriatric syndrome with a particular pathophysiology. There are different classification of osteoporosis: primary, in which bone loss is a result of aging and secondary, in which bone loss occurs from various clinical and lifestyle factors. [1]
Trochleitis is inflammation of the superior oblique tendon trochlea apparatus characterized by localized swelling, tenderness, and severe pain. This condition is an uncommon but treatable cause of periorbital pain. The trochlea is a ring-like apparatus of cartilage through which passes the tendon of the superior oblique muscle.
Other symptoms may include bone pain, weakness, depression, confusion, and increased urination. [1] [2] Both primary and secondary may result in osteoporosis (weakening of the bones). [2] [3] In 80% of cases, primary hyperparathyroidism is due to a single benign tumor known as a parathyroid adenoma.
In the 1900s polar explorers treated snow blindness by dripping cocaine into the eye. [19] Cool, wet compresses over the eyes and artificial tears may help local symptoms when the feeling returns. Nonsteroidal anti-inflammatory drug (NSAID) eyedrops are widely used to lessen inflammation and eye pain, but have not been proven in rigorous trials ...
Symptoms of optic neuritis in the affected eye include pain on eye movement, sudden loss of vision, and decrease in color vision (especially reds). Optic neuritis, when combined with the presence of multiple demyelinating white matter brain lesions on MRI, is suspicious for multiple sclerosis .