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Phenylbiguanide. Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system. [1] It has been found to trigger dopamine release in the nucleus accumbens of rats. [2]
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin receptors) which are G protein-coupled receptors. [1][2][3] This ion channel is cation -selective and mediates neuronal depolarization ...
The 5-HT3 antagonists, informally known as " setrons ", are a class of drugs that act as receptor antagonists at the 5-HT 3 receptor, a subtype of serotonin receptor found in terminals of the vagus nerve and in certain areas of the brain. With the notable exceptions of alosetron and cilansetron, which are used in the treatment of irritable ...
5 languages. العربية ... Pages in category "5-HT3 agonists" The following 17 pages are in this category, out of 17 total. ... Phenylbiguanide; Q. Quipazine; R ...
BMB-101 is a serotonin 5-HT 2C receptor agonist which is under development for the treatment of absence epilepsy, Pitt-Hopkins syndrome, Dravet syndrome, binge-eating disorder, Lennox-Gastaut syndrome, and opioid-related disorders.
Chlorophenylbiguanide. meta-Chlorophenylbiguanide (1- (3-Chlorophenylbiguanide, m-CPBG) is an allosteric agonist and modulator of the 5-HT 3 receptor [1][2][3] and an antagonist of the α 2A -adrenergic receptor. [4] It has anxiogenic, emetic and hypothermic effects in animal studies. [5][6][7][8]
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DOB-2-DRAGONFLY-5-BUTTERFLY is a drug with an unusual furo[2,3-g]chromene core structure which acts as a 5-HT 2A receptor agonist.It was first synthesised by David E. Nichols and colleagues in 2008, and while it is weaker than similar compounds such as Bromo-DragonFLY it is still the most potent among a number of related derivatives.