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A person must inherit two copies of the CFTR gene that contain mutations — one copy from each parent — to have cystic fibrosis. Every person has two copies of the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
In 1949, Lowe et al. postulated that cystic fibrosis must be caused by a genetic defect from the autosomal recessive pattern of inheritance of the disease. High levels of salt in the sweat of patients with cystic fibrosis suggested an abnormality in electrolyte transport from the sweat gland.
Cystic fibrosis is a common genetic disease within the white population in the United States. The disease occurs in 1 in 2,500 to 3,500 white newborns. Cystic fibrosis is less common in other ethnic groups, affecting about 1 in 17,000 African Americans and 1 in 31,000 Asian Americans.
Cystic fibrosis (CF) is a genetic disease. This means that it is inherited. A child will be born with CF only if they inherit one CF gene from each parent. A person who has only one CF gene is called a CF carrier. They are healthy and don't have the disease. But they are a carrier of the disease.
Genes are inherited in pairs, with one gene inherited from each parent to make the pair. Cystic fibrosis occurs when both genes in the pair have a mutation. A person with cystic fibrosis inherits one CF gene from each parent.
From the perspective of having the genetic disorder, cystic fibrosis follows an autosomal recessive inheritance pattern. It takes two non-working alleles to cause the disorder. From the perspective of the CFTR protein that is made, a person's two CFTR alleles are co-dominant.
There are. A person must inherit two CF genes to have CF disease. When your child was conceived,* he or she received a CF gene from both you and your partner. A many mutations* (abnormal genes) that have been shown to cause CF disease. Over 1000 mutations have about 30,000 children and adults in the United States have CF (about 70,000 worldwide).
Mode of Inheritance. Cystic fibrosis (CF) is inherited in an autosomal recessive manner.
A person must inherit two copies of the CFTR gene that contain mutations — one copy from each parent — to have cystic fibrosis. Cystic fibrosis occurs when the cystic fibrosis transmembrane conductance regulator (CFTR) protein is either not made correctly, or not made at all.
How CF is inherited? A person must inherit 2 CF genes to have CF disease. When your child was conceived, he or she received a CF gene from both you and your partner. A child can inherit CF only if both parents carry a CF gene (that is, each parent either has CF or is a carrier) and both parents pass the CF gene on to their child.