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Pyoderma gangrenosum is a rare, inflammatory skin disease where painful pustules or nodules become ulcers that progressively grow. [3] Pyoderma gangrenosum is not infectious. [3] Treatments may include corticosteroids, ciclosporin, infliximab, or canakinumab. [2] The disease was identified in 1930.
Treatments directed at tumor necrosis factor (infliximab, etanercept) and interleukin-1 have shown a good response in resistant arthritis and pyoderma gangrenosum. [10] [11] [12] Other traditional immunosuppressant treatments for arthritis or pyoderma gangrenosum may also be used. [citation needed]
Pathergy is a skin condition in which a minor trauma such as a bump or bruise leads to the development of skin lesions or ulcers that may be resistant to healing. Pathergy can also lead to ulcerations at the site of surgical incisions. Pathergy is seen with both Behçet's disease and pyoderma gangrenosum. [1]
Pyoderma gangrenosum is a less common skin problem, occurring in under 2%, [69] and is typically a painful ulcerating nodule. [68] [51] Clubbing, a deformity of the ends of the fingers, may also be a result of Crohn's disease. [70] [71]
A similar response occurs in pyoderma gangrenosum and Behcet's syndrome, and is referred to as pathergy. [3] Rarely Koebner phenomenon has been reported as a mechanism of acute myeloid leukemia dissemination. [4] Warts and molluscum contagiosum are often listed as causing a Koebner reaction, but this is by direct inoculation of viral particles. [3]
Ecthyma gangrenosum is a type of skin lesion characterized by vesicles or blisters, which rapidly evolve into pustules and necrotic ulcers with undermined tender erythematous border. " Ecthyma " means a pus-forming infection of the skin with an ulcer, "gangrenosum" refers to the accompanying gangrene or necrosis.
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Pyoderma means any skin disease that is pyogenic (has pus). These include superficial bacterial infections such as impetigo , impetigo contagiosa , ecthyma , folliculitis , Bockhart's impetigo , furuncle , carbuncle , tropical ulcer , etc. [ 1 ] [ 2 ] Autoimmune conditions include pyoderma gangrenosum .