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In childhood, T-cell acute lymphoblastic leukemia (T-ALL) patients can expect a 5-year event-free survival (EFS) rate of 70% and an overall survival (OS) rate of 80%. [1] Among the approximately 25% of children who relapse, survival rates drop to 30-50%, with patients generally showing a much poorer prognosis. [ 1 ]
Adult T-cell leukemia/lymphoma (ATL or ATLL) is a rare cancer of the immune system's T-cells [1] [2] [3] caused by human T cell leukemia/lymphotropic virus type 1 . [4] All ATL cells contain integrated HTLV-1 provirus further supporting that causal role of the virus in the cause of the neoplasm. [ 4 ]
In the United States during 2013–2017, the age-adjusted mortality rate for all types of cancer was 189.5/100,000 for males, and 135.7/100,000 for females. [1] Below is an incomplete list of age-adjusted mortality rates for different types of cancer in the United States from the Surveillance, Epidemiology, and End Results program.
People in pediatric care with ALL in developed countries have a greater than 80% five-year survival rate. It is estimated that 60–80% of adults undergoing induction chemotherapy achieve complete remission after 4 weeks, and those over the age of 70 have a cure rate of 5%. [48] [75]
Overall, among people diagnosed between ages 15 and 39, deaths from all causes from five through 10 years after diagnosis dropped to 5.4% among those diagnosed with cancer in 2005-2011, from 8.3% ...
T-cell leukemia describes several different types of lymphoid leukemia which affect T cells. Types include: [1] Large granular lymphocytic leukemia; Adult T-cell leukemia/lymphoma; T-cell prolymphocytic leukemia; In practice, it can be hard to distinguish T-cell leukemia from T-cell lymphoma, and they are often grouped together.
T-cell prolymphocytic leukemia (T-PLL) is a very rare and aggressive leukemia affecting adults; somewhat more men than women are diagnosed with this disease. [24] Despite its overall rarity, it is the most common type of mature T cell leukemia; [25] nearly all other leukemias involve B cells. It is difficult to treat, and the median survival is ...
As the name suggests, T-cell large granular lymphocyte leukemia is characterized by involvement of cytotoxic-T cells). [2] In a study based in the US, the average age of diagnosis was 66.5 years [3] whereas in a French study the median age at diagnosis was 59 years (with an age range of 12–87 years old). [4] In the French study, only 26% of ...