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Selective reabsorption is the process whereby certain molecules (e.g. ions, glucose and amino acids), after being filtered out of the capillaries along with nitrogenous waste products (i.e. urea) and water in the glomerulus, are reabsorbed from the filtrate as they pass through the nephron. [1]
Most of the reabsorption (65%) occurs in the proximal tubule. In the latter part it is favored by an electrochemical driving force, but initially it needs the cotransporter SGLT and the Na-H antiporter. Sodium passes along an electrochemical gradient (passive transport) from the lumen into the tubular cell, together with water and chloride ...
Reabsorption is a two-step process beginning with the active or passive extraction of substances from the tubule fluid into the renal interstitium (the connective tissue that surrounds the nephrons), and then the transport of these substances from the interstitium into the bloodstream.
Renal glucose reabsorption is the part of kidney (renal) physiology that deals with the retrieval of filtered glucose, preventing it from disappearing from the body through the urine. If glucose is not reabsorbed by the kidney, it appears in the urine, in a condition known as glycosuria. This is associated with diabetes mellitus. [1]
A loss of the foot processes of the podocytes (i.e., podocyte effacement) is a hallmark of minimal change disease, which has therefore sometimes been called foot process disease. [ 17 ] Disruption of the filtration slits or destruction of the podocytes can lead to massive proteinuria , where large amounts of protein are lost from the blood.
The electrical and concentration gradient drives more reabsorption of Na +, as well as other cations such as magnesium (Mg 2+) and calcium (Ca 2+). Cortical thick ascending limb; The cortical thick ascending limb drains urine into the distal convoluted tubule. [3] The tissue type of the loop is simple squamous epithelium.
This process is called ultrafiltration; the resulting fluid, virtually free of large proteins and blood cells, is referred to as glomerular filtrate, or ultrafiltrate. [1] Further modification of ultrafiltrate, by reabsorption and secretion, transforms it into urine. Glomerular pressure is about 75 millimeters of mercury (10 kPa). It is opposed ...
Reabsorption allows many useful solutes (primarily glucose and amino acids), salts and water that have passed through Bowman's capsule, to return to the circulation. These solutes are reabsorbed isotonically , in that the osmotic potential of the fluid leaving the proximal convoluted tubule is the same as that of the initial glomerular filtrate.