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H&E stain. Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) or Reed's syndrome is rare autosomal dominant disorder associated with benign smooth muscle tumors and an increased risk of renal cell carcinoma. It is characterised by multiple cutaneous leiomyomas and, in women, uterine leiomyomas. It predisposes individuals to renal cell ...
Papillary renal cell carcinoma (PRCC) is a malignant, heterogeneous tumor originating from renal tubular epithelial cells of the kidney, which comprises approximately 10-15% of all kidney neoplasms. [ 1 ] Based on its morphological features, PRCC can be classified into two main subtypes, which are type 1 (basophilic) and type 2 (eosinophilic).
Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine. RCC is the most common type of kidney cancer in adults, responsible for approximately 90–95% of cases. [ 1 ] It is more common in men (with a male-to-female ...
Hereditary bilateral, multifocal kidney tumors similar to those seen in BHD can occur with von Hippel–Lindau disease (clear cell renal cell carcinoma), hereditary papillary renal cancer (papillary renal cell carcinoma), and hereditary leiomyomatosis and renal cell cancer syndrome. They are differentiated with examination of the tumors' histology.
Hereditary cancer syndromes underlie 5 to 10% of all cancers and there are over 50 identifiable hereditary forms of cancer. [5] Scientific understanding of cancer susceptibility syndromes is actively expanding: additional syndromes are being found, [6] the underlying biology is becoming clearer, and genetic testing is improving detection, treatment, and prevention of cancer syndromes. [7]
Other mutant alleles of the FH gene, located on human chromosome 1 at position 1q42.1, cause multiple cutaneous and uterine leiomyomata, hereditary leiomyomatosis and renal cell cancer. [5] Fumarase deficiency is one of the few known deficiencies of the Krebs cycle or tricarboxylic acid cycle, the main enzymatic pathway of cellular aerobic ...
Kidney cancer, also known as renal cancer, is a group of cancers that starts in the kidney. [ 4 ] Symptoms may include blood in the urine, a lump in the abdomen, or back pain. [ 1 ][ 2 ][ 3 ] Fever, weight loss, and tiredness may also occur. [ 1 ][ 2 ][ 3 ] Complications can include spread to the lungs or brain. [ 6 ]
H&E stain. Wilms' tumor or Wilms tumor, [ 3 ] also known as nephroblastoma, is a cancer of the kidneys that typically occurs in children (rarely in adults), [ 4 ] and occurs most commonly as a renal tumor in child patients. [ 5 ][ 6 ] It is named after Max Wilms, the German surgeon (1867–1918) who first described it.
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