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Severe adverse effects may include angioedema, low blood pressure, and kidney problems. [4] Use during pregnancy may result in harm to the baby. [4] [1] Use is not recommended during breastfeeding. [1] It works by blocking angiotensin II. [4] Losartan was patented in 1986, and approved for medical use in the United States in 1995.
Hypertension and the brain. Hypertension is a condition characterized by an elevated blood pressure in which the long term consequences include cardiovascular disease, kidney disease, adrenal gland tumors, vision impairment, memory loss, metabolic syndrome, stroke and dementia. [1] It affects nearly 1 in 2 Americans and remains as a ...
Losartan, the first ARB. Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT 1) antagonists, [1] also known as angiotensin receptor blockers, [2] [3] angiotensin II receptor antagonists, or AT 1 receptor antagonists, are a group of pharmaceuticals that bind to and inhibit the angiotensin II receptor type 1 (AT 1) and thereby block the arteriolar contraction and ...
AT 2 receptors are more plentiful in the fetus and neonate. The AT 2 receptor remains enigmatic and controversial – is probably involved in vascular growth. Effects mediated by the AT 2 receptor are suggested to include inhibition of cell growth, fetal tissue development, modulation of extracellular matrix, neuronal regeneration, apoptosis, cellular differentiation, and maybe vasodilation ...
Drug-induced angioedema. Other names. Acquired angioedema. Specialty. Dermatology. Drug-induced angioedema is a known complication of the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II antagonists (ARBs), and Angiotensin-Neprilysin Inhibitor LCZ969. [ 1 ]: 120 The angioedema appears to be dose dependent as it may resolve ...
Specialty. Ophthalmology, optometry. Anterior ischemic optic neuropathy (AION) is a medical condition involving loss of vision caused by damage to the anterior portion of the optic nerve as a result of insufficient blood supply (ischemia). This form of ischemic optic neuropathy is generally categorized as two types: arteritic AION (or AAION ...
DTXSID80166052. Losartan/hydrochlorothiazide, sold under the brand name Hyzaar among others, is a fixed-dose combination medication used to treat high blood pressure when losartan is not sufficient. [1][2] It consists of losartan, an angiotensin II receptor blocker; and hydrochlorothiazide, a thiazide diuretic. [1][2] It is taken by mouth. [1][2]
"When we focus our eyes on something close up, like a screen or even a book, our eyes are strained and contracted, which can cause eye discomfort. But if you look ahead to a distant object, our ...