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Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
Haemochromatosis is protean in its manifestations, i.e., often presenting with signs or symptoms suggestive of other diagnoses that affect specific organ systems.Many of the signs and symptoms below are uncommon, and most patients with the hereditary form of haemochromatosis do not show any overt signs of disease nor do they have premature morbidity, if they are diagnosed early, but, more ...
A heart attack can cause symptoms such as: Chest pain that often radiates to your left shoulder, neck, or arm. Abdominal pain. Shortness of breath. Fatigue. Pressure or heaviness in your chest ...
[1] [4] In cases where high doses of elemental iron have been ingested and the patient is exhibiting signs and symptoms of severe systemic iron poisoning, supportive care measures like volume resuscitation and deferoxamine should be initiated immediately. [4] A quick response to iron poisoning can significantly improve clinical outcomes.
Iron deficiency is more common in women than in men, and it often goes undiagnosed. ... “Picking it up early can lead to it being treated early and potentially prevent anemia and other symptoms ...
Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the circulation in mammals. [6]During conditions in which the hepcidin level is abnormally high, such as inflammation, serum iron falls due to iron trapping within macrophages and liver cells and decreased gut iron absorption.
Quadrants of the abdomen Diagram showing which organs (or parts of organs) are in each quadrant of the abdomen. The left lower quadrant (LLQ) of the human abdomen is the area left of the midline and below the umbilicus. The LLQ includes the left iliac fossa and half of the left flank region. The equivalent term for animals is left posterior ...
An analysis of data from more than 8,000 adults in the U.S. revealed that 14% had low iron blood levels, a condition known as absolute iron deficiency, while 15% had the right iron levels but ...
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