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It is the major cause of liver disease in Western countries, and is the leading cause of death from excessive drinking. [2] [3] Although steatosis (fatty liver disease) will develop in any individual who consumes a large quantity of alcoholic beverages over a long period of time, this process is transient and reversible. [1]
Alcoholic liver disease is a major public health problem. For example, in the United States up to two million people have alcohol-related liver disorders. [149] Chronic heavy alcohol consumption can cause fatty liver, cirrhosis, and alcoholic hepatitis. Treatment options are limited and consist of most importantly discontinuing alcohol consumption.
"Fatty liver disease, particularly NAFLD, is emerging as a leading cause of chronic liver disease, cirrhosis and liver cancer, as well as an important risk factor for type 2 diabetes and ...
Fatty liver disease happens when fat builds up in your liver. This can cause damage, inflammation, and other complications. Fatty Liver Disease: What Men Need to Know
Because ethanol is mostly metabolized and consumed by the liver, chronic excessive use can lead to fatty liver. This leads to a chronic inflammation of the liver and eventually alcoholic liver disease. Alcohol consumption can cause hypoglycemia in diabetics on certain medications, such as insulin or sulfonylurea, by blocking gluconeogenesis. [65]
[44] [32] Cirrhosis caused by hepatitis C and alcoholic liver disease are the most common reasons for liver transplant. [32] Both hepatitis C and hepatitis B–related cirrhosis can also be attributed with heroin addiction. [54] Chronic hepatitis B causes liver inflammation and injury that over several decades can lead to cirrhosis. [44]
These methods can help reveal fatty deposits in the liver and rule out other causes of liver damage. Related: 4 Science-Backed Ways to Keep Your Liver Healthy 5 Sneaky Signs You Might Have NAFLD
This causes many of the sequelae of chronic liver disease including esophageal varices (with associated variceal bleeding), ascites and splenomegaly. The chronic inflammation seen in alcoholic hepatitis also leads to impaired hepatocyte differentiation, impairments in hepatocyte regeneration and hepatocyte de-differentiation into cholangiocyte ...
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