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A study conducted by the pharmaceutical company Smith, Kline & French (SKF) in 1947 showed that amphetamine can affect the brain center for appetite and help to reduce weight. In the late 1960s, weight reduction was the most common indication for ATS. [5] Nowadays, to suppress appetite, phentermine is still used. [2]
Amphetamine is a weak base with a pK a of 9.9; [3] consequently, when the pH is basic, more of the drug is in its lipid soluble free base form, and more is absorbed through the lipid-rich cell membranes of the gut epithelium. [3] [29] Conversely, an acidic pH means the drug is predominantly in a water-soluble cationic (salt) form, and less is ...
In 1959, phentermine first received approval from the US Food and Drug Administration (FDA) as an appetite suppressant. [43] Eventually a hydrochloride salt and a resin form became available. [43] Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen ...
Phenmetrazine, sold under the brand name Preludin among others, is a stimulant drug first synthesized in 1952 and originally used as an appetite suppressant, but withdrawn from the market in the 1980s due to widespread misuse.
Phendimetrazine possesses preferable pharmacokinetics over phenmetrazine as a therapeutic agent because its metabolization by demethylases produces a more steady and prolonged exposure of active drug within the body. This decreases abuse potential as the peak blood-concentration of active phenmetrazine that's produced from a single dose of ...
Lisdexamfetamine, sold under the brand names Vyvanse and Elvanse among others, is a stimulant medication that is used to treat attention deficit hyperactivity disorder (ADHD) in children and adults and for moderate-to-severe binge eating disorder in adults. [16]
The good news is that there are plenty of healthy and effective ways to suppress your appetite for weight loss without resorting to extreme measures. From simple lifestyle changes to smart food ...
The drug's main function is to reduce appetite, which in turn reduces caloric intake. [medical citation needed] Although the mechanism of action of the sympathomimetic appetite suppressants in the treatment of obesity is not fully known, these medications have pharmacological effects similar to those of amphetamines.