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OT can modify heart rates and cause excessive fluid intake (antidiuretic effect). Intravenous infusion (IV) of oxytocin is often used to induce labor and enhance milk lactation during postpartum care. IV use can cause side-effects such as cardiovascular manifestations in the form of tachycardia and bradycardia. In addition, nausea, vomiting ...
Synthetic oxytocin, sold under the brand name Pitocin among others, is a medication made from the peptide oxytocin. [6] [7] As a medication, it is used to cause contraction of the uterus to start labor, increase the speed of labor, and to stop bleeding following delivery. [6]
Oxytocin/ergometrine (trade name Syntometrine) is an obstetric combination drug. The components are synthetically produced oxytocin , a human hormone produced in the hypothalamus , and ergometrine , an alpha-adrenergic , dopaminergic and serotonin (5-HT 2 ) receptor agonist.
Oxytocin is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. [4] Present in animals since early stages of evolution, in humans it plays roles in behavior that include social bonding, love, reproduction, childbirth, and the period after childbirth.
For example, when oxytocin is released during a contraction of the uterus at the start of childbirth, this stimulates production and release of more oxytocin and an increase in the duration, intensity and frequency of contractions. This process compounds in intensity and frequency and continues until the triggering activity ceases.
During human parturition, the quantifiable level of blood plasma oxytocin rises: it becomes twice as much during the initial phase of dilation and continues to increase until the second stage of labor. [36] Oxytocin furthermore induces uterine contractions in mothers following childbirth which helps in the prevention of bleeding. [37]
Sucking causes the pituitary gland to release oxytocin, which contracts the uterus and prevents bleeding. [1] [6] This can be felt by the mother in the breasts. The crying of the infant can also induce the release of oxytocin. Cracked nipples can develop at this time, which can be managed with pharmacological and nonpharmacological treatment. [4]
It is given intravenously since it is easily degraded by the body if given orally. While giving oxytocin, it is important to monitor the mother and the fetus, specifically the mother's uterine activity and the fetal heart rate. The more common side effects of oxytocin include tachysystole, hyponatremia, and hypotension. Tachysystole is an ...
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