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  2. Paradoxical reaction - Wikipedia

    en.wikipedia.org/wiki/Paradoxical_reaction

    Naltrexone blocks the opioid receptors, acting opposite to most opioid pain medications. [22] It can be used to negate the effects of opioid painkillers. At doses around one-tenth of the typical dose, naltrexone has been used for pain relief. Low-dose naltrexone is believed to have an anti-inflammatory effect. This is an off-label use and not ...

  3. Serotonin–norepinephrine–dopamine reuptake inhibitor

    en.wikipedia.org/wiki/Serotonin–norepinephrine...

    These drugs inhibit the uptake of the neurotransmitter 5-HT by blocking the SERT, thus increasing its synaptic concentration, and have shown to be efficacious in the treatment of depression, however sexual dysfunction and weight gain are two very common side-effects that result in discontinuation of treatment.

  4. Cocaine - Wikipedia

    en.wikipedia.org/wiki/Cocaine

    Cutting or "stepping on" the drug is commonplace, using compounds which simulate ingestion effects, such as Novocain (procaine) producing temporary anesthesia, as many users believe a strong numbing effect is the result of strong and/or pure cocaine, ephedrine or similar stimulants that are to produce an increased heart rate. The normal ...

  5. As overdose rates rise, FDA calls for new medications to help ...

    www.aol.com/news/why-no-treatments-cocaine-meth...

    There's renewed urgency to help people with stimulant use disorders as drugs like cocaine and meth have become cheaper, easier to find and more potent. Now, the need for treatments has crashed ...

  6. Stimulant - Wikipedia

    en.wikipedia.org/wiki/Stimulant

    A systematic review of cardiovascular effects of prescription stimulants found no association in children, but found a correlation between prescription stimulant use and ischemic heart attacks. [16] A review over a four-year period found that there were few negative effects of stimulant treatment, but stressed the need for longer-term studies. [17]

  7. Depressant - Wikipedia

    en.wikipedia.org/wiki/Depressant

    In contrast, stimulants, or "uppers", increase mental alertness, making stimulants the opposite drug class from depressants. Antidepressants are defined by their effect on mood, not on general brain activity, so they form an orthogonal category of drugs. Depressants are closely related to sedatives as a category of drugs, with significant ...

  8. Doctors increasingly prescribing amphetamines along with ...

    www.aol.com/news/doctors-increasingly...

    A large number of U.S. adults are being prescribed drugs like amphetamines, which have a risk for misuse, along with medications for depression and anxiety, a new study has found.. The practice ...

  9. Opioid - Wikipedia

    en.wikipedia.org/wiki/Opioid

    This requires them to increase their drug dosage to maintain the benefit, and that in turn also increases the unwanted side effects. [78] Long-term opioid use can cause opioid-induced hyperalgesia, which is a condition in which the patient has increased sensitivity to pain. [101] All of the opioids can cause side effects. [70]