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Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic to be discovered. [6] It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.
Individual dogs of any breed can have a profound reaction characterized by hypotension, especially if there is an underlying heart problem. In giant-breed dogs and sighthounds , the sedative effects of acepromazine may last for 12–24 hours, which is much longer than the usual 3–4 hours.
JNJ-7777120 was a drug being developed by Johnson & Johnson Pharmaceutical Research & Development which acts as a potent and selective antagonist at the histamine H 4 receptor. [1]
Celexa – an antidepressant of the SSRI class; Centrax – an anti-anxiety agent; Clozaril – atypical antipsychotic used to treat resistant schizophrenia; Concerta (methylphenidate) – an extended release form of methylphenidate
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Quetiapine and clozapine are considered the lowest risk agents for precipitating TD. [25] From 2008, there have been reported cases of the anti-psychotic medication aripiprazole, a partial agonist at D2 receptors, leading to tardive dyskinesia. [26] As of 2013, reports of tardive dyskinesia in aripiprazole have grown in number. [27]
Clozapine N-oxide (CNO) is a synthetic drug used mainly in biomedical research as a ligand to activate Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), [1] despite the initial belief that it was biologically inert.
Clotiapine (Entumine) is an atypical antipsychotic [2] of the dibenzothiazepine chemical class. [3] It was first introduced in a few European countries (namely, Belgium, Italy, Spain and Switzerland), Argentina, Taiwan and Israel in 1970.