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The location of NORs and the nucleolar cycle in human cells. Nucleolus organizer regions (NORs) are chromosomal regions crucial for the formation of the nucleolus.In humans, the NORs are located on the short arms of the acrocentric chromosomes 13, 14, 15, 21 and 22, the genes RNR1, RNR2, RNR3, RNR4, and RNR5 respectively. [1]
Nucleoli are made of proteins, DNA and RNA, and form around specific chromosomal regions called nucleolar organizing regions. Malfunction of the nucleolus is the cause of several human conditions called "nucleolopathies" [3] [4] and the nucleolus is being investigated as a target for cancer chemotherapy. [5] [6]
Flinders (formerly named Number 6 in series 1) is a very old Numtum and gives the Numtums adventures in his green number six. Humpty Do (formerly named Number 7 in series 1 and also known as Humpty) is the hungriest Numtum in his light blue number seven. Coogee (formerly named Number 8 in series 1) is a baby in his yellow number eight.
A bedroom or bedchamber is a room situated within a residential or accommodation unit characterized by its usage for sleeping. A typical western bedroom contains as bedroom furniture one or two beds, a clothes closet, and bedside table and dressing table, both of which usually contain drawers.
small nucleolar RNA multiple families: snRNA: small nuclear RNA multiple families: snRNP: small nuclear ribonucleic proteins - SPA lncRNA 5' small nucleolar RNA capped and 3' polyadenylated long noncoding RNA - SRP RNA: signal recognition particle RNA CL00003: ssRNA single stranded RNA - stRNA: small temporal RNA - tasiRNA: trans-acting siRNA ...
The specificity of the antibodies is 98% and 99.6% in other rheumatic diseases and normal individuals, respectively. [8] [33] In addition to scleroderma, these antibodies are found in approximately 5% of individuals with SLE. [34] The antigenic target of anti-Scl-70 antibodies is topoisomerase I. [35]
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