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addiction; schizophrenia; Nigrostriatal pathway: The nigrostriatal pathway transmits dopaminergic neurons from the zona compacta of the substantia nigra [8] to the caudate nucleus and putamen. The substantia nigra is located in the midbrain, while both the caudate nucleus and putamen are located in the dorsal striatum. motor function; reward ...
The ventral tegmental area is in the midbrain between several other major areas, some of which are described here. The mammillary bodies and the posterior hypothalamus, both included in the diencephalon, extend rostrally from the VTA. The red nucleus is situated laterally and oculomotor fibers are situated ventromedially to the VTA. [5]
The mesolimbic pathway and a specific set of the pathway's output neurons (e.g. D1-type medium spiny neurons within the nucleus accumbens) play a central role in the neurobiology of addiction. [20] [21] [22] Drug addiction is an illness caused by habitual substance use that induces chemical changes in the brain's circuitry. [23]
The midbrain tegmentum is also an important part of the dopaminergic system which is essential for feelings of reward and pleasure. Two regions in the midbrain tegmentum are of particular interest. The first one is the substantia nigra which is an important part of the nigrostriatal pathway. This pathway serves to coordinate motor movements and ...
The substantia nigra is located in the ventral midbrain of each hemisphere. It has two distinct parts, the pars compacta (SNc) and the pars reticulata (SNr). The pars compacta contains dopaminergic neurons from the A9 cell group that forms the nigrostriatal pathway that, by supplying dopamine to the striatum, relays information to the basal ganglia.
Cross-section of the midbrain. Tectum. Corpora quadrigemina. Inferior colliculi; Superior colliculi; Pretectum; Tegmentum. Periaqueductal gray; Rostral interstitial nucleus of medial longitudinal fasciculus; Midbrain reticular formation; Dorsal raphe nucleus; Red nucleus; Ventral tegmental area. Parabrachial pigmented nucleus; Paranigral ...
Stimulation of the periaqueductal gray matter of the midbrain activates enkephalin-releasing neurons that project to the raphe nuclei in the brainstem. 5-HT released from the raphe nuclei descends to the dorsal horn of the spinal cord where it forms excitatory connections with the inhibitory interneurons located in Laminae II (aka the substantia gelatinosa).
The midbrain or mesencephalon is the uppermost portion of the brainstem connecting the diencephalon and cerebrum with the pons. [2] It consists of the cerebral peduncles , tegmentum , and tectum . It is functionally associated with vision, hearing, motor control, sleep and wakefulness, arousal ( alertness ), and temperature regulation.