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  2. Discovery and development of proton pump inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    A derivative of timoprazole, omeprazole, was discovered in 1979, and was the first of a new class of drug that control acid secretion in the stomach, a proton pump inhibitor (PPI). [11] [12] Addition of 5-methoxy-substitution to the benzimidazole moiety of omeprazole was also made and gave the compound much more stability at neutral pH. [6]

  3. Omeprazole - Wikipedia

    en.wikipedia.org/wiki/Omeprazole

    Omeprazole was a subject of a patent litigation in the U.S. [66] The invention involved application of two different coatings to a drug in pill form to ensure that the omeprazole did not disintegrate before reaching its intended site of action in stomach. Although the solution by means of two coating was obvious, the patent was found valid ...

  4. List of withdrawn drugs - Wikipedia

    en.wikipedia.org/wiki/List_of_withdrawn_drugs

    [17]: 12 Reintroduced as a dietary supplement in 2006; [17]: 13 in 2013 the FDA started work to ban it due to cardiovascular problems [18] Dinoprostone: 1990 UK Uterine hypotonus, fetal distress. [3] Dipyrone 1975 UK, US, Others Agranulocytosis, anaphylactic reactions. [3] Dithiazanine iodide: 1964 France, US

  5. Montel Williams Recalls 'Taking 12 to 13' Pills a Day: 'As ...

    www.aol.com/lifestyle/montel-williams-recalls...

    Montel Williams remembers how easy it once was to build a stockpile of opioids when he was on the road. “As celebrities, we can get whatever we want,” Williams, 68, tells Maria Menounos on the ...

  6. New Year's resolutions for NFL teams: Lions, 49ers, Vikings ...

    www.aol.com/sports/years-resolutions-nfl-teams...

    In this episode of Football 301, Nate Tice and Matt Harmon are ringing in the New Year with their resolutions for NFL teams as the playoff race heats up. Matt's resolutions focus on teams in the ...

  7. Amazon donating $1 million to Trump inauguration, airing ...

    www.aol.com/amazon-donating-1-million-trump...

    It also will air the Jan. 20 event on Prime Video. Tech giant Amazon joins Meta in donating $1 million to President-elect Trump's inauguration fund. It also will air the Jan. 20 event on Prime Video.

  8. Proton-pump inhibitor - Wikipedia

    en.wikipedia.org/wiki/Proton-pump_inhibitor

    Most of these medications are benzimidazole derivatives, related to omeprazole, but imidazopyridine derivatives such as tenatoprazole have also been developed. [77] Potassium-competitive inhibitors such as revaprazan reversibly block the potassium-binding site of the proton pump, acting more quickly, but are not available in most countries.

  9. Is Your Dog Stressed? 5 Signs to Watch for and How to Help - AOL

    www.aol.com/dog-stressed-5-signs-watch-151500398...

    Comfort food: This may not work with all dogs, and since dogs are very smart, they might figure out that to get treats or other comfort food, all they have to do is act stressed. If your dog is ...