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Immunohistochemistry for CK7 of a metastatic undifferentiated carcinoma to a lymph node. Because the keratin-7 antigen is found in both healthy and neoplastic cells, antibodies to CK7 can be used in immunohistochemistry to distinguish ovarian and transitional cell carcinomas (staining positive) from colonic and prostate cancers (negative), respectively.
Prostate cancer staging is the process by which physicians categorize the risk of cancer having spread beyond the prostate, or equivalently, the probability of being cured with local therapies such as surgery or radiation. Once patients are placed in prognostic categories, this information can contribute to the selection of an optimal approach ...
Micrograph of adenosquamous carcinoma of the pancreas. Light microscopy shows a combination of gland-like cells and squamous epithelial cells. [4] On immunohistochemistry, it is typically positive for CK5/6, CK7 and p63, and negative for CK20, p16 and p53. On genetic testing, KRAS and p53 are typically altered. [4]
In immunohistochemistry, antibodies to CK20 can be used to identify a range of adenocarcinoma arising from epithelia that normally contain the CK20 protein. For example, the protein is commonly found in colorectal cancer , transitional cell carcinomas and in Merkel cell carcinoma , but is absent in lung cancer , prostate cancer , and non ...
In the United States there has been an increase in the 5-year relative survival rate between people diagnosed with cancer in 1975-1977 (48.9%) and people diagnosed with cancer in 2007-2013 (69.2%); these figures coincide with a 20% decrease in cancer mortality from 1950 to 2014. [8]
Men whose cancer has metastasized to a nearby part of the body (around 15% of diagnoses) have poorer prognoses, with five-year survival rates of 60–80%. [1] Those with metastases in distant body sites (around 5% of diagnoses) have relatively poor prognoses, with five-year survival rates of 30–40%. [1]
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Properties of common prostate cancer cell lines. PC3 (PC-3) is a human prostate cancer cell line used in prostate cancer research and drug development. [1] PC3 cells are useful in investigating biochemical changes in advanced prostate cancer cells and in assessing their response to chemotherapeutic agents. PC3 cells are also used to study viral ...
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