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The disease referred to a chronic progressive adrenal insufficiency, and was described in 1855 by the Englishman Thomas Addison, who gave it his name, Addison's disease. [9] The cardinal signs included asthenia , low blood pressure , anorexia (with weight loss) and melanoderma, with hyperpigmentation of the skin at friction points and of the ...
Hyperpigmentation as seen in a woman with Addison's disease. The symptoms of Addison's disease can develop over several months and resemble other medical conditions. [14] Most common symptoms are caused by low levels of hormones that would normally be produced by the adrenal glands.
Most people with primary Addison's disease have darkening (hyperpigmentation) of the skin, including areas not exposed to the sun; characteristic sites are skin creases (e.g. of the hands), nipple, and the inside of the cheek (buccal mucosa), new scars become hyperpigmented, whereas older ones do not darken.
What is Addison’s disease? Addison’s disease is an autoimmune condition — affecting about one in 100,000 people — in which the body attacks its organs, specifically the adrenal glands. It ...
The most common cause of primary adrenal insufficiency (Addison's disease) overall is autoimmune adrenalitis. [2] The prevalence of Addison's disease ranges from 5 to 221 per million in different countries. [30] In children, congenital adrenal hyperplasia (CAH) is the most common cause of adrenal insufficiency, with an incidence 1 in 14,200 ...
Hyperpigmentation is associated with a number of diseases or conditions, including the following: Addison's disease and other sources of adrenal insufficiency, in which hormones that stimulate melanin synthesis, such as melanocyte-stimulating hormone (MSH), are frequently elevated.
Addison's disease can be caused by a variety of pathological processes. It is an endocrinal disorder where there is an increased amount of adrenocorticotropic hormone (ACTH) as a result of deficient amounts of hormones being produced from the adrenal cortex. [9] Due to this, dark pigmentation may be visible on the oral mucosa or skin. [10]
Acanthosis nigricans is a medical sign characterised by brown-to-black, poorly defined, velvety hyperpigmentation of the skin. [1] It is usually found in body folds, [2] such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead and other areas.