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Labetalol is often classified as a beta blocker with low lipophilicity and hence lower potential for crossing the blood–brain barrier and blood–placenta barrier. [17] [29] [30] This in turn may result in fewer effects in the central nervous system as well as a lower risk of neuropsychiatric side effects. [17]
Beta blockers vary in their lipophilicity (fat solubility) and in turn in their ability to cross the blood–brain barrier and exert effects in the central nervous system. [76] Beta blockers with greater blood–brain barrier permeability can have both neuropsychiatric therapeutic benefits and side effects, as well as adverse cognitive effects ...
Figure 1: The chemical structure of dichloroisoprenaline or dichloroisoproterenol (), abbreviated DCI — the first β-blocker to be developed. β adrenergic receptor antagonists (also called beta-blockers or β-blockers) were initially developed in the 1960s, for the treatment of angina pectoris but are now also used for hypertension, congestive heart failure and certain arrhythmias. [1]
There are a few possible side effects linked to taking NSAIDs, including: gastrointestinal problems (such as irritation, ulcers, or bleeding), increased risk of heart attack and stroke, reduced ...
The choice between the drugs is to a large degree determined by the characteristics of the patient being prescribed for, the drugs' side effects, and cost. Most drugs have other uses; sometimes the presence of other symptoms can warrant the use of one particular antihypertensive.
However, some side effects can occur, such as palpitation, tremor, elevated blood pressure, and anxiety. [23] Yohimbe bark contains both α 1 and α 2 adrenergic receptors blocking alkaloids . Phentolamine , a non-selective alpha blocker, has also been tested to treat erectile dysfunction.
[2] [3] This may be done with labetalol or sodium nitroprusside given by injection into a vein. [2] In those who are pregnant, magnesium sulfate may be used. [2] Other treatments may include anti-seizure medications. [2] Hypertensive encephalopathy is uncommon. [2] It is believed to occur more often in those without easy access to health care. [2]
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