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In July 2024, the US Food and Drug Administration (FDA) approved Felanorm, the first generic methimazole oral solution for the treatment of hyperthyroidism in cats. [26] [27] [28] Felanorm contains the same active ingredient (methimazole) as the approved brand name drug product, Felimazole Coated Tablets, which were first approved in May 2009. [26]
Most are in the US. UC Davis have since abandoned their program. Kidney transplantation is a controversial treatment option, with longevity, quality of life, as well as ethical considerations. The United Kingdom permitted this procedure in 2003, but a review in 2013 suspended it. Many argue that it causes unnecessary suffering to donor animals. [2]
Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Methimazole prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T 3 and T 4 . It is on the World Health Organization's List of Essential Medicines.
A systematic review from 2016 found that metamizole significantly increased the relative risk of upper gastrointestinal bleeding, by a factor of 1.4–2.7 times. [31] A study by one of the manufacturers of the drug found the risk of agranulocytosis within the first week of treatment to be a 1.1 in a million, versus 5.9 in a million for diclofenac.
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The biological monitoring working party (BMWP) is a procedure for measuring water quality using families of macroinvertebrates as biological indicators. [ 1 ] The method is based on the principle that different aquatic invertebrates have different tolerances to pollutants .
Methazolamide (trade name Neptazane) is a potent carbonic anhydrase inhibitor.It is indicated in the treatment of increased intraocular pressure (IOP) in chronic open-angle glaucoma and secondary glaucoma.
Old Possum's Book of Practical Cats (1939) is a collection of whimsical light poems by T. S. Eliot about feline psychology and sociology, published by Faber and Faber. It serves as the basis for Andrew Lloyd Webber 's 1981 musical Cats .